Today we are going to delve into the fascinating world of Metitepine, a topic that has captivated the attention of people of all ages and cultures throughout history. Metitepine is an inexhaustible source of inspiration and fascination, whether due to its impact on society, its relevance in the scientific field, its influence on popular culture or its transformative power in people's lives. Throughout this article, we will explore the different aspects of Metitepine, from its origins to its latest trends, to better understand its importance and impact on the modern world.
The reduction of 2-(4-methylsulfanylphenyl)sulfanylbenzoic acid, CID:2733664 (1) gives methanol, CID:12853582 (2). Halogenating with thionyl chloride gives 1-(chloromethyl)-2-(4-methylsulfanylphenyl)sulfanylbenzene, CID:12853583 (3). FGI with cyanide gives 2-acetonitrile, CID:12853584 (4). Alkali hydrolysis of the nitrile to 2-acetic acid, CID:12383832 (5). PPA cyclization to 3-methylsulfanyl-6H-benzobenzothiepin-5-one, CID:827052 (6). The reduction with sodium borohydride gives 3-methylsulfanyl-5,6-dihydrobenzobenzothiepin-5-ol, CID:13597048 (7). Halogenating with a second round of thionyl chloride gives 5-chloro-3-methylsulfanyl-5,6-dihydrobenzobenzothiepine, CID:12404411. Alkylation with 1-methylpiperazine completed the synthesis of Metitepine (9).
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