Timiperone

In the modern world, Timiperone has gained great interest and relevance in different areas of society. With the advancement of technology and globalization, Timiperone has become a constant topic of conversation, ranging from cultural and artistic to scientific and political aspects. The influence of Timiperone has spread worldwide, generating debates and conflicting opinions in public opinion. In this article, we will explore different perspectives and approaches around Timiperone, to better understand its impact on our daily lives and in the future.

Timiperone
Clinical data
Trade namesTolopelon
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-(4-fluorophenyl)-4-butan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.055.328 Edit this at Wikidata
Chemical and physical data
FormulaC22H24FN3OS
Molar mass397.51 g·mol−1
3D model (JSmol)
  • C1CN(CCC1N2C3=CC=CC=C3NC2=S)CCCC(=O)C4=CC=C(C=C4)F
  • InChI=1S/C22H24FN3OS/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28) ☒N
  • Key:YDLQKLWVKKFPII-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Timiperone, sold under the brand name Tolopelon, is a typical antipsychotic of the butyrophenone class which is marketed in Japan for the treatment of schizophrenia.[1][2][3][4] It is similar in chemical structure to benperidol, but has a thiourea group instead of a urea group. It acts as an antagonist for the D2 and 5-HT2A receptors.[4]

References

  1. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1030–. ISBN 978-3-88763-075-1.
  2. ^ Yamasaki T, Kojima H, Tanaka M, Aibara S, Hirohashi M, Kasai Y, et al. (1981). "Pharmacological studies on timiperone, a new neuroleptic drug Part II: General pharmacological properties". Arzneimittel-Forschung. 31 (4): 707–15. PMID 6113834.
  3. ^ Tanaka M, Kojima H, Akashi A (November 1985). "Effect of timiperone, a new antipsychotic drug, on the sleep-wakefulness cycle in cats". Japanese Journal of Pharmacology. 39 (3): 391–4. doi:10.1254/jjp.39.391. PMID 2869168.
  4. ^ a b Miyamoto S (2010). "Timiperone". In Stolerman IP (ed.). Encyclopedia of Psychopharmacology. Berlin, Heidelberg: Springer. p. 1323. doi:10.1007/978-3-540-68706-1_1902. ISBN 978-3-540-68706-1. Retrieved 2022-03-11.
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