Lecozotan

In this article, we will explore the fascinating world of Lecozotan. From its origin to its impact on today's society, we will delve into its many facets and discover its influence in different areas. Lecozotan has been the subject of study and debate throughout history, awakening the interest of specialists and amateurs alike. Along these lines, we will examine its origins, evolution and its relevance in the current context, offering a complete and detailed vision of Lecozotan. Likewise, we will analyze its impact in different areas, highlighting its role in culture, technology, politics and much more. Get ready to embark on a fascinating journey through Lecozotan!

Lecozotan
Identifiers
  • 4-Cyano-N-propyl]-N-2-pyridinylbenzamide hydrochloride
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H30ClN5O3
Molar mass520.03 g·mol−1
3D model (JSmol)
  • C(CN(C1=CC=CC=N1)C(=O)C2=CC=C(C=C2)C#N)N3CCN(CC3)C4=C5C(=CC=C4)OCCO5
  • InChI=1S/C28H29N5O3/c1-21(31-13-15-32(16-14-31)24-5-4-6-25-27(24)36-18-17-35-25)20-33(26-7-2-3-12-30-26)28(34)23-10-8-22(19-29)9-11-23/h2-12,21H,13-18,20H2,1H3/t21-/m1/s1
  • Key:NRPQELCNMADTOZ-OAQYLSRUSA-N
  (verify)

Lecozotan is an investigational drug by Wyeth tested for improvement of cognitive functions of Alzheimer's disease patients. As of June 2008, the first Phase III clinical trial has been completed.

Method of action

Lecozotan is a competitive, selective 5-HT1A receptor antagonist which enhances the potassium-stimulated release of acetylcholine and glutamate.

References

  1. ^ Spreitzer H (August 13, 2008). "Neue Wirkstoffe - Lecozotan". Österreichische Apothekerzeitung (in German) (17/2007): 805.
  2. ^ ClinicalTrials
  3. ^ Schechter LE, Smith DL, Rosenzweig-Lipson S, Sukoff SJ, Dawson LA, Marquis K, et al. (September 2005). "Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties". The Journal of Pharmacology and Experimental Therapeutics. 314 (3): 1274–89. arXiv:1506.05421. doi:10.1124/jpet.105.086363. PMID 15951399. S2CID 16444551.
  4. ^ Childers Jr WE, Harrison, BL, Abou-Gharbia, MA, Raje, S, Parks, V, Pangalos, MN, Schechter, LE (2007). "Lecozotan Hydrochloride". Drugs of the Future. 32 (5): 399–407. doi:10.1358/dof.2007.032.05.1092901.


Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

Wikious
Boobota
Sagapedia