Thiopurine
In this article, we will delve into the fascinating world of Thiopurine. From its origins to its relevance in today's society, we will explore all aspects related to Thiopurine and its impact in different areas. Through a detailed tour, we will discover the multiple facets that make Thiopurine a topic of universal interest. We will analyze its evolution over time, its influence on popular culture, its relevance in the academic field and its implications in the contemporary context. Get ready to immerse yourself in an enriching journey that will allow you to deeply understand the importance and significance of Thiopurine in our society.
The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis), and organ transplant recipients.
Metabolism is catalyzed by S-methyltransferase and nudix hydrolase 15 (NUDT15).
Litigation over patents covering diagnostic kits to monitor the dosing of these drugs led to a US Supreme Court case, Mayo Collaborative Services v. Prometheus Laboratories, Inc. that dramatically changed the nature of patent law in the United States.
See also
- 6-Mercaptopurine (6-MP)
- 6-Thioguanine (6-TG)
- Azathioprine (AZA)
References
- ^ Sahasranaman S, Howard D, Roy S (August 2008). "Clinical pharmacology and pharmacogenetics of thiopurines". Eur. J. Clin. Pharmacol. 64 (8): 753–67. doi:10.1007/s00228-008-0478-6. PMID 18506437.
- ^ Supreme Court Decision. Mayo Collaborative Services v. Prometheus Laboratories, Inc., No. 10-1150, Slip Op. at 16. Decision
- ^ Gene Quinn, Killing Industry: The Supreme Court Blows Mayo v. Prometheus IP Watchdog (March 20, 2012).
External links
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