SN-2

In this article, we will explore various aspects related to SN-2, with the aim of delving into its meaning, importance and relevance in different areas. From its impact on today's society to its influence in specific areas, SN-2 has captured the attention of experts and scholars from different disciplines. Through a detailed and multifaceted analysis, different perspectives will be presented that will allow readers to fully understand the importance of SN-2 and its impact on the contemporary world. This article seeks to provide a comprehensive and enriching vision of SN-2, providing relevant and updated information that contributes to the knowledge and understanding of this topic.

SN-2
Identifiers
  • 5-(2,4,6-trimethylphenyl)-3-oxa-4-azatricyclodec-4-ene
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H21NO
Molar mass255.361 g·mol−1
3D model (JSmol)
  • CC1=CC(=C(C(=C1)C)C2=NOC3C2C4CCC3C4)C
  • InChI=1S/C17H21NO/c1-9-6-10(2)14(11(3)7-9)16-15-12-4-5-13(8-12)17(15)19-18-16/h6-7,12-13,15,17H,4-5,8H2,1-3H3
  • Key:WKLZNTYMDOPBSE-UHFFFAOYSA-N

SN-2 is a chemical compound which acts as an "agonist" (i.e. channel opener) for the TRPML3 calcium channel, with high selectivity for TRPML3 and no significant activity at the related TRPML1 and TRPML2 channels. It has demonstrated antiviral activity in an in vitro model.

See also

References

  1. ^ Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, et al. (February 2010). "Small molecule activators of TRPML3". Chemistry & Biology. 17 (2): 135–48. doi:10.1016/j.chembiol.2009.12.016. PMC 2834294. PMID 20189104.
  2. ^ Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, et al. (October 2020). "ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity". Antiviral Research. 182: 104922. doi:10.1016/j.antiviral.2020.104922. PMID 32858116. S2CID 221365410.