6-Fluoronorepinephrine

In today's world, 6-Fluoronorepinephrine is an issue that has taken on great relevance in society. With the advancement of technology and globalization, 6-Fluoronorepinephrine has become an issue that affects all people to a greater or lesser extent. Whether on a personal, professional or social level, 6-Fluoronorepinephrine has a direct impact on our daily lives. For this reason, it is essential to understand its importance and influence on different aspects of today's society. In this article, we will further explore 6-Fluoronorepinephrine and discuss its implications in various contexts.
6-Fluoronorepinephrine
Clinical data
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 4-(2-amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC8H10FNO3
Molar mass187.170 g·mol−1
3D model (JSmol)
  • Fc1cc(O)c(O)cc1C(O)CN
  • InChI=1S/C8H10FNO3/c9-5-2-7(12)6(11)1-4(5)8(13)3-10/h1-2,8,11-13H,3,10H2 checkY
  • Key:SBUQBFTXTZSRMH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

6-Fluoronorepinephrine (6-FNE) is a selective α1- and α2-adrenergic receptor full agonist related to norepinephrine.[1][2] It is the only selective full agonist for the α-adrenergic receptors known to date and has been used to study their function in scientific research.[2] Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α1-adrenergic receptors.[2][3]

References

  1. ^ Kirk KL, Cantacuzene D, Nimitkitpaisan Y, McCulloh D, Padgett WL, Daly JW, Creveling CR (1979). "Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines". Journal of Medicinal Chemistry. 22 (12): 1493–7. doi:10.1021/jm00198a012. PMID 231654.
  2. ^ a b c Stone EA, Lin Y, Sarfraz Y, Quartermain D (2009). "Marked behavioral activation from inhibitory stimulation of locus coeruleus α1-adrenoceptors by a full agonist". Brain Research. 1291: 21–31. doi:10.1016/j.brainres.2009.07.049. PMC 2735576. PMID 19632210.
  3. ^ Stone EA, Grunewald GL, Lin Y, Ahsan R, Rosengarten H, Kramer HK, Quartermain D (2003). "Role of epinephrine stimulation of CNS α1-adrenoceptors in motor activity in mice". Synapse. 49 (1): 67–76. doi:10.1002/syn.10212. PMID 12710017. S2CID 35324292.
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