Small cleaved cells

In the following article we will explore in depth the fascinating world of Small cleaved cells. From its origins to its impact today, we will delve into the multiple aspects that make Small cleaved cells a topic of interest for people of all ages and professions. Throughout these pages, we will discover the importance of Small cleaved cells in modern society and the relevance it has in various areas. Whether you are an expert in the field or are discovering Small cleaved cells for the first time, this article will provide you with a complete and up-to-date overview of this exciting topic.

Small cleaved cells are a distinctive type of cell that appears in certain types of lymphoma.

When used to uniquely identify a type of lymphoma, they are usually categorized as follicular (C82.0) or diffuse (C83.1) .

The "small cleaved cells" are usually centrocytes that express B-cell markers such as CD20. The disease is strongly correlated with the genetic translocation t(14;18), which results in juxtaposition of the bcl-2 proto-oncogene with the heavy chain JH locus, and thus in overexpression of bcl-2. Bcl-2 is a well known anti-apoptotic gene, and thus its overexpression results in the "failure to die" motif of cancer seen in follicular lymphoma.

Follicular lymphoma must be carefully monitored, as it often progresses into a more aggressive "Diffuse Large B-Cell Lymphoma."

  • Abe M, Wakasa H (1994). "Histogenesis and pathogenesis of follicular small cleaved cell lymphoma (FSCCL), diffuse small cleaved cell lymphoma (DSCCL) and intermediate lymphocytic lymphoma/lymphocytic lymphoma of intermediate differentiation (ILL/IDL)". Fukushima J Med Sci. 40 (2): 85–101. PMID 7642169.
  • Abe M, Ono N, Tominaga K, Hojo H, Seto M, Fukuhara S, Wakasa H (1992). "Histogenesis of diffuse small cleaved cell lymphoma. An immunohistochemical and molecular genetic (bcl-2 gene) study with comparison to follicular small cleaved cell lymphoma and mantle zone lymphoma". Cancer. 70 (4): 821–9. doi:10.1002/1097-0142(19920815)70:4<821::AID-CNCR2820700417>3.0.CO;2-Y. PMID 1643614.
  • Lymphoma,+Small+Cleaved-Cell,+Follicular at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Lymphoma,+Small+Cleaved-Cell,+Diffuse at the U.S. National Library of Medicine Medical Subject Headings (MeSH)


Stub icon

This article related to pathology is a stub. You can help Wikipedia by expanding it.

Wikious
Boobota
Sagapedia