Pentolame

Today we are going to talk about Pentolame, a topic that has captured the attention of millions of people around the world. Pentolame is a topic of great importance in today's society, and its relevance is reflected in the diversity of opinions it raises. From its impact on people's daily lives to its implications in areas such as politics, economics and culture, Pentolame has been the subject of intense debate and analysis. In this article we will explore different aspects related to Pentolame, with the aim of understanding its scope and influence on our contemporary reality.
Pentolame
Clinical data
Other names17β-((5-Hydroxypentyl)amino)estradiol; 17β-estra-1,3,5(10)-trien-3-ol
Identifiers
  • (8R,9S,13S,14S,17S)-17-(5-Hydroxypentylamino)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopentaphenanthren-3-ol
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H35NO2
Molar mass357.538 g·mol−1
3D model (JSmol)
  • C12CC3(1CC2NCCCCCO)CCC4=C3C=CC(=C4)O
  • InChI=1S/C23H35NO2/c1-23-12-11-19-18-8-6-17(26)15-16(18)5-7-20(19)21(23)9-10-22(23)24-13-3-2-4-14-25/h6,8,15,19-22,24-26H,2-5,7,9-14H2,1H3/t19-,20-,21+,22+,23+/m1/s1
  • Key:CYIRNKIFROUCMA-VROINQGHSA-N

Pentolame, also known as 17β-((5-hydroxypentyl)amino)estradiol is a synthetic, steroidal estrogen and a 17β-aminoestrogen with anticoagulant effects that was first described in 1993 and was never marketed.[1][2][3]

References

  1. ^ Lemini C, Rubio-Póo C, Silva G, García-Mondragón J, Zavala E, Mendoza-Patiño N, Castro D, Cruz-Almanza R, Mandoki JJ (1993). "Anticoagulant and estrogenic effects of two new 17 beta-aminoestrogens, butolame and pentolame ". Steroids. 58 (10): 457–61. doi:10.1016/0039-128x(93)90002-5. PMID 8256254. S2CID 54381037.
  2. ^ Lemus AE, Jaimez R, Lemini C, Menjivar M, Silva G, Rubio-Poo C, Valenzuela F, Larrea F (1998). "Estrogenic effects of the synthetic aminoestrogen 17 beta-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol (pentolame)". Steroids. 63 (7–8): 433–8. doi:10.1016/s0039-128x(98)00046-4. PMID 9654651. S2CID 13582499.
  3. ^ Jaimez R, Cooney A, Jackson K, Lemus AE, Lemini C, Cárdenas M, García R, Silva G, Larrea F (2000). "In vivo estrogen bioactivities and in vitro estrogen receptor binding and transcriptional activities of anticoagulant synthetic 17beta-aminoestrogens". J. Steroid Biochem. Mol. Biol. 73 (1–2): 59–66. doi:10.1016/s0960-0760(00)00053-4. PMID 10822025. S2CID 40211307.


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