PEAQX

In today's world, PEAQX has become increasingly relevant. Since its emergence, PEAQX has captured the attention of people around the world due to its impact on different aspects of daily life. Whether in the personal, social, political, economic or cultural sphere, PEAQX has proven to be a topic of general interest for various audiences. That is why in this article we will thoroughly explore the importance of PEAQX, its evolution over time and its influence on today's society. Through detailed analysis, we aim to offer a comprehensive perspective on PEAQX and its role in the contemporary world.

PEAQX
Clinical data
Other namesPEAQX, NVP-AAM077
Identifiers
  • ({amino}-(2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methyl)phosphonic acid
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC17H17BrN3O5P
Molar mass454.217 g·mol−1
3D model (JSmol)
  • C(C1=CC=C(C=C1)Br)NC(C2=C3C(=CC=C2)N=C(C(=N3)O)O)P(=O)(O)O
  • InChI=1S/C17H17BrN3O5P/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26)/t9-,17?/m0/s1 ☒N
  • Key:XXZGNAZRWCBSBK-WFVOFKTRSA-N ☒N
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PEAQX is a competitive antagonist at the NMDA receptor. Although originally described as 100-fold selective for GluN1/GluN2A receptors vs. GluN1/GluN2B receptors, more detailed studies of the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is also a potent anticonvulsant in animal tests.

References

  1. ^ Frizelle PA, Chen PE, Wyllie DJ (September 2006). "Equilibrium constants for (R)--(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of synaptic transmission". Molecular Pharmacology. 70 (3): 1022–32. doi:10.1124/mol.106.024042. PMID 16778008. S2CID 14304805.
  2. ^ Auberson YP, Allgeier H, Bischoff S, Lingenhoehl K, Moretti R, Schmutz M (April 2002). "5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition". Bioorganic & Medicinal Chemistry Letters. 12 (7): 1099–102. doi:10.1016/s0960-894x(02)00074-4. PMID 11909726.
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