Fibrinoid necrosis

Today, Fibrinoid necrosis is a topic that has gained indisputable relevance in modern society. From Fibrinoid necrosis people have debated its impact on our lives, its influence on different aspects of culture and its role in the evolution of technology. This phenomenon has sparked increasing interest in various fields, from politics and economics to psychology and medicine. In this article, we will explore the various facets of Fibrinoid necrosis and its importance in today's world, examining its impact on society and its potential to transform the way we think and act.

Micrograph showing (intensely pink) fibrinoid necrosis (large blood vessel – right of image) in a case of vasculitis (eosinophilic granulomatosis with polyangiitis). H&E stain.

Fibrinoid necrosis is a specific pattern of irreversible, uncontrolled cell death that occurs when antigen-antibody complexes are deposited in the walls of blood vessels along with fibrin. It is common in the immune-mediated vasculitides which are a result of type III hypersensitivity. When stained with hematoxylin and eosin, they appear brightly eosinophilic and smudged.

Diseases

Fibrinoid necrosis is not limited to the immune-mediated vasculitides; many pathologic processes can lead to areas of fibrinoid necrosis. In systemic lupus erythematosus, the dermis is often affected by fluid accumulation and inflammation around the small vessels in the skin, which may show prominent fibrinoid necrosis. Also it's seen in rheumatoid nodules with similar pathology. Also seen in Serum Sickness(Type III hypersensitivity reaction)

References

  1. ^ a b Robbins and Cotran pathologic basis of disease. Kumar, Vinay, Abbas, Abul K., Aster, Jon C., Perkins, James A. (Ninth ed.). Philadelphia, PA. 2014. ISBN 9781455726134. OCLC 879416939.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
Stub icon

This article related to pathology is a stub. You can help Wikipedia by expanding it.

Wikious
Boobota
Sagapedia