In today's world, Dehydrodolichyl diphosphate synthase has become a topic of great relevance and interest to a wide spectrum of society. Since its emergence, Dehydrodolichyl diphosphate synthase has captured the attention of academics, experts, professionals and the general public, generating a debate in which multiple points of view are presented and different aspects related to this topic are analyzed. Over time, Dehydrodolichyl diphosphate synthase has evolved, adapting to the changes and challenges that arise in today's world, and its influence has extended to various spheres, from politics and economics, to culture and entertainment. In this article we will explore the most relevant aspects of Dehydrodolichyl diphosphate synthase, examining its impact on society and its role in the contemporary world.
Dehydrodolichyl diphosphate synthase is an enzyme that in humans is encoded by the DHDDSgene.[5][6]
Function
Dehydrodolichyl diphosphate (dedol-PP) synthase catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins.[6]
Clinical significance
It has been suggested that missense mutations in the DHDDS gene are responsible for certain variants of retinitis pigmentosa.[7] Since it is involved in the early steps of dolichol synthesis, vital e.g. for correct N-glycosylation, a disease caused by mutations in DHDDS should be considered a congenital disorder of glycosylation (and named DHDDS-CDG according to the novel nomenclature of CDGs).[8] Many CDG subtypes present with retinitis pigmentosa as a major feature.[9]
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Shridas P, Rush JS, Waechter CJ (2004). "Identification and characterization of a cDNA encoding a long-chain cis-isoprenyltranferase involved in dolichyl monophosphate biosynthesis in the ER of brain cells". Biochem. Biophys. Res. Commun. 312 (4): 1349–56. doi:10.1016/j.bbrc.2003.11.065. PMID14652022.
