In this article we are going to delve into the fascinating world of DAMGO. We will explore its origins, its relevance in today's society and its impact on different aspects of daily life. From the historical perspective to its evolution today, DAMGO has been the subject of study and debate, generating great interest among academics, lovers of the subject, and society in general. Through this article, we will seek to shed light on DAMGO, providing a panoramic view that allows the reader to understand its importance and influence in the contemporary world.
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IUPAC name
(2S)-2-amino]propanoyl]amino]acetyl]-methylamino]-N-(2-hydroxyethyl)-3-phenylpropanamide
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Other names
Ala2-MePhe4-Glyol5-Enkephalin, DAGO, DAMGE
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C26H35N5O6 | |
Molar mass | 513.595 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
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DAMGO (-enkephalin) is a synthetic opioid peptide with high μ-opioid receptor specificity. It was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-enkephalin. Structures of DAMGO bound to the μ opioid receptor reveal a very similar binding pose to morphinans.
Its structure is H-Tyr-D-Ala-Gly-N-MePhe-Gly-ol.
DAMGO has been used in experimental settings for the possibility of alleviating or reducing opiate tolerance for patients under the treatment of an opioid. Such treatment on rats, adding DAMGO to morphine administration, showed that after seven days morphine had as much of an effect at the same dosage as the first day when administered together with DAMGO to the rats, whereas a separate control group of rats that were administered the same dosage of morphine over the course of the same week, but without DAMGO, displayed an increased tolerance and lessened analgesic efficacy toward the end of that week.