Clopamide

In this article we will explore in detail Clopamide, a topic of great relevance and interest today. Clopamide is a concept that has generated great controversy and debate in various spheres, from the academic field to the field of politics and society in general. Over the years, Clopamide has played a fundamental role in the way we perceive and understand the world around us, its implications have been profound and have given rise to a wide range of divergent opinions and perspectives. Through a comprehensive analysis, this article will seek to shed light on the complexity and relevance of Clopamide, examining its historical roots, its current impacts and its projection into the future.
Clopamide
Clinical data
Trade namesBrinaldix
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-
    benzamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.010.238 Edit this at Wikidata
Chemical and physical data
FormulaC14H20ClN3O3S
Molar mass345.84 g·mol−1
3D model (JSmol)
  • O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N
  • InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21) checkY
  • Key:LBXHRAWDUMTPSE-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Clopamide (trade name Brinaldix) is a piperidine diuretic.[1]

Mechanism of action

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.

References

  1. ^ McNeil JJ, Conway EL, Drummer OH, Howes LG, Christophidis N, Louis WJ (September 1987). "Clopamide: plasma concentrations and diuretic effect in humans". Clinical Pharmacology and Therapeutics. 42 (3): 299–304. doi:10.1038/clpt.1987.151. PMID 3621784. S2CID 20000178.
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