Calphostin

In this article, we will explore the exciting world of Calphostin and all the facets that involve it. From its origins to its impact on today's society, Calphostin is a topic that deserves detailed and thoughtful attention. Along these lines, we will analyze its relevance in different contexts, as well as the controversies and debates that surround it. With a critical and objective approach, we will delve into Calphostin to understand its importance and challenges today. This article will undoubtedly provide a comprehensive overview of Calphostin and leave the reader with a greater understanding and appreciation for this topic.

The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.[1][2] The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC).[1][2] The most potent member of the series, calphostin C,[1] has found use as a biochemical tool because of this activity.[3]

Calpohostin R1 R2
Calphostin A Bz Bz
Calphostin B Bz H
Calphostin C Bz 4-(HO)Bz
Calphostin D H H
Calphostin I 4-(HO)Bz 4-(HO)Bz

Calphostin C

Main article: Calphostin C

Calphostin C is a potent inhibitor of protein kinase C (PKC).[1][2][3]

References

  1. ^ a b c d Kobayashi, E; Ando, K; Nakano, H; Iida, T; Ohno, H; Morimoto, M; Tamaoki, T (1989). "Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities". Journal of Antibiotics. 42 (10): 1470–1474. doi:10.7164/antibiotics.42.1470. PMID 2478514.
  2. ^ a b c Iida, T; Kobayashi, E; Yoshida, M; Sano, H (1989). "Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures". Journal of Antibiotics. 42 (10): 1475–1481. doi:10.7164/antibiotics.42.1475. PMID 2478515.
  3. ^ a b "Calphostin C". Biomol GmbH. Retrieved 11 October 2024.
Wikious
Boobota
Sagapedia