CSPG5

In this article, we will explore the fascinating world of CSPG5, addressing its most relevant and significant aspects. From its origins to its impact today, we will dive into an exhaustive analysis of CSPG5, delving into its implications and scope over time. Through this journey, we aim to shed light on CSPG5, offering a comprehensive and enriching vision for all those interested in acquiring greater knowledge about this topic. Thus, we will embark on an exciting and revealing journey, which will allow us to understand the importance of CSPG5 in contemporary society and its relevance in various areas of daily life.

Protein-coding gene in the species Homo sapiens

CSPG5
Identifiers
Aliases	CSPG5, NGC, chondroitin sulfate proteoglycan 5
External IDs	OMIM: 606775; MGI: 1352747; HomoloGene: 4795; GeneCards: CSPG5; OMA:CSPG5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 47,562,238 bp End 47,580,792 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F2 Start 110,072,851 bp End 110,091,644 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell retinal pigment epithelium frontal pole Brodmann area 23 Epithelium of choroid plexus Brodmann area 10 Region I of hippocampus proper orbitofrontal cortex entorhinal cortex Brodmann area 46 Top expressed in visual cortex primary visual cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus cingulate gyrus prefrontal cortex nucleus of stria terminalis primary motor cortex anterior amygdaloid area piriform cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding growth factor activity Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane plasma membrane integral component of plasma membrane extracellular region cell surface lysosomal lumen endoplasmic reticulum Golgi lumen Golgi-associated vesicle membrane glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane Biological process cell differentiation chondroitin sulfate biosynthetic process modulation of chemical synaptic transmission intracellular transport nervous system development multicellular organism development chondroitin sulfate catabolic process regulation of growth dermatan sulfate biosynthetic process regulation of signaling receptor activity trans-synaptic signaling, modulating synaptic transmission regulation of synaptic vesicle exocytosis cytoskeleton organization glial cell projection elongation positive regulation of substrate adhesion-dependent cell spreading signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10675 29873 Ensembl ENSG00000114646 ENSMUSG00000032482 UniProt O95196 Q71M36 RefSeq (mRNA) NM_006574 NM_001206942 NM_001206943 NM_001206944 NM_001206945 NM_001166273 NM_013884 RefSeq (protein) NP_001193871 NP_001193872 NP_001193873 NP_001193874 NP_006565 NP_001159745 NP_038912 Location (UCSC) Chr 3: 47.56 – 47.58 Mb Chr 9: 110.07 – 110.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.

Interactions

CSPG5 has been shown to interact with GOPC.

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000114646 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000032482 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Yasuda Y, Tokita Y, Aono S, Matsui F, Ono T, Sonta S, Watanabe E, Nakanishi Y, Oohira A (May 1999). "Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module". Neurosci Res. 32 (4): 313–22. doi:10.1016/S0168-0102(98)00098-4. PMID 9950058. S2CID 39609929.
6. ^ "Entrez Gene: CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)".
7. ^ Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. 278 (41). United States: 40136–43. doi:10.1074/jbc.M305577200. ISSN 0021-9258. PMID 12885772.

Further reading

• Ichihara-Tanaka K, Oohira A, Rumsby M, Muramatsu T (2006). "Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells". J. Biol. Chem. 281 (41): 30857–64. doi:10.1074/jbc.M602228200. PMID 16901907.
• Aono S, Tokita Y, Yasuda Y, et al. (2006). "Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain". J. Neurosci. Res. 83 (1): 110–8. doi:10.1002/jnr.20698. PMID 16299773. S2CID 45306074.
• Kinugasa Y, Ishiguro H, Tokita Y, et al. (2004). "Neuroglycan C, a novel member of the neuregulin family". Biochem. Biophys. Res. Commun. 321 (4): 1045–9. doi:10.1016/j.bbrc.2004.07.066. PMID 15358134.
• Hassel B, Schreff M, Stube EM, et al. (2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. 278 (41): 40136–43. doi:10.1074/jbc.M305577200. PMID 12885772.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

External links

• Human CSPG5 genome location and CSPG5 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

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