Benzothiadiazine

In the following article, we will delve into the exciting world of Benzothiadiazine and explore its many facets. From its intriguing origin to its current repercussions, we will delve into this topic to unravel its secrets. Through exhaustive analysis and a critical approach, we aim to shed light on Benzothiadiazine, offering our readers a comprehensive and informed view of this fascinating field. Join us on this tour of Benzothiadiazine and discover everything behind this enigmatic universe.
Benzothiadiazine
Names
Preferred IUPAC name
2H-1,2,4-Benzothiadiazine
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C7H6N2S/c1-2-4-7-6(3-1)5-8-9-10-7/h1-5,9H checkY
    Key: HAVZTGSQJIEKPI-UHFFFAOYSA-N checkY
  • InChI=1/C7H6N2S/c1-2-4-7-6(3-1)5-8-9-10-7/h1-5,9H
    Key: HAVZTGSQJIEKPI-UHFFFAOYAH
  • c1ccc2SN\N=C/c2c1
Properties
C7H6N2S
Molar mass 150.20 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
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Benzothiadiazine is a chemical compound that consists of a benzene ring fused to a thiadiazine ring. Thiadiazine in turn is a six-membered heterocycle composed of three carbon atoms, one sulfur atom, and two nitrogen atoms.[1]

Some benzothiadiazine derivatives are used as pharmaceutical drugs, including:

Hydrochlorothiazide, a benzothiadiazine derivative used as a diuretic

References

  1. ^ Hu Z, Martí J, Lu H (October 2021). "Structure of benzothiadiazine at zwitterionic phospholipid cell membranes". The Journal of Chemical Physics. 155 (15): 154303. arXiv:2107.14565. Bibcode:2021JChPh.155o4303H. doi:10.1063/5.0065163. PMID 34686044. S2CID 239471390.
  2. ^ a b Hu Z, Marti J (March 2022). "In Silico Drug Design of Benzothiadiazine Derivatives Interacting with Phospholipid Cell Membranes". Membranes. 12 (3): 331. doi:10.3390/membranes12030331. PMC 8949146. PMID 35323806.
  3. ^ Huwaimel BI, Bhakta M, Kulkarni CA, Milliken AS, Wang F, Peng A, et al. (April 2021). "Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity*". ChemMedChem. 16 (7): 1143–1162. doi:10.1002/cmdc.202000729. PMC 8035258. PMID 33331124.
  4. ^ Varano F, Catarzi D, Colotta V, Squarcialupi L, Matucci R (November 2014). "1,2,4-Benzothiadiazine-1,1-dioxide derivatives as ionotropic glutamate receptor ligands: synthesis and structure-activity relationships". Archiv der Pharmazie. 347 (11): 777–785. doi:10.1002/ardp.201400192. PMID 25204434. S2CID 1765795.
  5. ^ Ganeshpurkar A, Gutti G, Singh SK (2019-01-01). "Chapter 1 - RNA-Dependent RNA Polymerases and Their Emerging Roles in Antiviral Therapy". In SP (ed.). Viral Polymerases. Academic Press. pp. 1–42. doi:10.1016/B978-0-12-815422-9.00001-2. ISBN 978-0-12-815422-9. S2CID 92095885.
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